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T16133 |
MRK-560
|
|
Gamma-secretase
|
|
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase. |
|
T6603 |
Nelarabine
|
GW 506U78,Nelzarabine,506U78 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
|
|
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
|
T3977 |
Lifitegrast
|
SHP-606,SAR 1118 |
Integrin
|
|
Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist. |
|
T0370 |
Pheniramine maleate
|
Daneral,Inhiston,Trimetose |
5-HT Receptor
,
Histamine Receptor
|
|
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... |
|
T64387 |
2-Nitrobenzoic acid
|
o-Nitrobenzoic acid |
Others
|
|
2-Nitrobenzoic acid (o-Nitrobenzoic acid) is a antiproliferation agent. 2-Nitrobenzoic acid shows IC50 of 8.3 μM to jurkat cell line expressing T type calcium channel alpha 1H or its splice variant delta 25. |
|
T35569 |
CTA 056
|
|
Apoptosis
|
|
CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel... |
|
T10565 |
BMS-1001 hydrochloride
|
|
PD-1/PD-L1
|
|
BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activat... |
|
T24816 |
SP-100030
|
SP100030,SP 100030 |
NF-κB
|
|
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ... |
|
T39342 |
4-Maleimidosalicylic acid
|
|
|
|
4-Maleimidosalicylic acid is a polar maleimide compound that does not exhibit suppressive effects on IL-2 production in JURKAT T cells. |
|
T80497 |
KTX-Sp2
|
|
Potassium Channel
|
|
KTX-Sp2, a potassium channel toxin, effectively blocks exogenous voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.3, as well inhibits the endogenous Kv1.3 channel and suppresses Ca2+ signaling in Jurkat T cells. Ad... |
|
T12203L |
Necrostatin 2
|
|
Others
|
|
|
|
TP2101 |
Z-VRPR-FMK trifluoroacetate salt
|
|
|
|
Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable. |
|
T36331 |
Z-AEVD-FMK
|
Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone |
|
|
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its activ... |
|
T35906 |
Padanamide A
|
|
|
|
Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines... |
|
T79705 |
LP23
|
|
PD-1/PD-L1
|
|
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/Jurkat T cells and induction of HepG2 cell death. Additionally, LP2... |
|
T74843 |
ITK degrader 1
|
|
|
|
ITK Degrader 1, a highly selective interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice) degrader, induces rapid and prolonged degradation of ITK and effectively suppresses IL-2 secretion (EC50=35.2 nM... |
|
T79314 |
PD-L1-IN-3
|
|
PD-1/PD-L1
|
|
PD-L1-IN-3 (Compound 4a) functions as an inhibitor targeting the PD-1/PD-L1 axis, with an IC50 value of 4.97nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1... |
|
T36034 |
CAY10774
|
|
|
|
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay).1It increases the activation of Jurkat... |
|
T35940 |
Darinaparsin
|
Dimethylarsinic glutathione,Darinaparsin |
|
|
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM)... |
|
T35775 |
HT-2 Toxin-13C22
|
HT-2 Toxin-13C22 |
|
|
HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene... |
|
T83763 |
EPI-X4 TFA
|
Endogenous Peptide Inhibitor of CXCR4 |
|
|
EPI-X4, an endogenous peptide fragment of human serum albumin (amino acids 408-423), serves as an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4). It effectively prevents calcium mobilization and receptor in... |
|
T69221 |
BMS-554417
|
|
|
|
BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 fo... |
